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Hydrogen/deuterium exchange (HDX) combined with mass spectrometry (MS) provides a powerful combination of technologies for the analysis of biotherapeutic protein conformation and examination of higher-order structural dynamics and epitope mapping.
Advances in HDX/MS hardware and software offer biopharmaceutical scientists the ability to monitor the changes in higher-order structure of a therapeutic protein, and examine the protein dynamics and association with other proteins and biomolecules. The powerful combination of Ultra Performance Liquid Chromatography (UPLC), dedicated HDX fluidic automation, high-resolution time-of-flight (Tof) and ion-mobility Tof (IMS-Tof) mass spectrometry, along with purpose-driven software, delivers high spatial resolution and analytical reproducibility with minimal sample consumption.
In this seminar, the first—and only—commercially available system for HDX studies will be discussed by scientists in academia and industry who are actively using the technology in their research. They will illustrate how this automated system removes previous barriers and enables them to readily achieve routine and robust high-performance analytics. Our panelists will also describe how the system's dedicated HDX processing software simplifies studies of higher-order biotherapeutic protein structure for a variety of applications.
Panelists in this webinar will describe the underlying principles and benefits of HDX/MS analysis, and will demonstrate specific applications of the technology for rapid and meaningful comparability studies.
