Level 10 Smeargle defeats multiple Kecleons at Mt. Horn in Pokémon Mystery Dungeon: Explorers of Darkness. The Smeargle has a moveset consisting of Endeavor, Endure, Psywave, and Ominous Wind.
Endure allows Smeargle to survive any hit with 1 HP. Endeavor reduces the target's HP down to the user's HP, which, assuming Endure took effect, is equal to 1. Psywave does damage equal to a random fraction of the user's level, so it is effectively a strange cousin of the moves Night Shade and Seismic Toss. Gravelerocks, Geo Pebbles, and Blast Seeds can also be used to bypass Kecleon's absurdly high stats to do constant damage.
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