Chad gives a thorough presentation covering Friedel-Crafts Alkylation and Friedel-Crafts Acylation. He begins with the mechanism of the Friedel-Crafts Alkylation and reveals the three shortcomings of the reaction:
1) The reaction is prone to occur multiple times (polyalkylation),
2) It is subject to rearrangements,
3) It doesn't work with strongly deactivated benzenes

Chad then presents the mechanism for the Friedel-Crafts Acylation and goes on to show how it is not subject to the first two shortcomings experienced by Friedel-Crafts Alkylations. Finally, Chad concludes the lesson with the Gattermann-Koch reaction, functionally a special case of the Friedel-Crafts Acylation.

Do you want Chad’s Organic Chemistry Study Guides and Practice Quizzes/Tests?
Check out Chad’s Organic Chemistry Master Course. Free Trial available!
[ Ссылка ]

00:00 Lesson Introduction
00:39 Friedel-Crafts Alkylation
07:57 Friedel-Crafts Acylation
13:49 Gattermann-Koch Reaction

[ Ссылка ]

свернуть