SULFONYLUREAS
Antidiabetic Drugs Recap ✍🏻
Mechanism of action, adverse effects, fun fact!

Mechanism of action:
Increases the insulin secretion in the pacreatic beta cells (bind to potassium channels which close, leading to membrane depolarisation, calcium levels increase, which promotes ultimately insulin secretion).

Important:

Gliclazide (safer)
VS.
Glibenclamide
(long duration, increased risk of hypoglaecemia - therefore contraindicated in elderly)

Adverse effects
Hypoglycaemia (especially in long-acting agents or high doses);
Weight gain (almost inevitable; counterbalance with diet restrictions)
Can accelarate beta cells dysfunction (mechanism is explained - and because their function may deteorate with time in type 2 diabetes - when this happens patient should be started on insulin).

Fun fact:
Sulfonylureas are chemically similar to sufonamide antibiotics (but no antibiotic properties). Due to this: combination with trimethoprim or co-trimoxazole can increase the hypoglycaemia risk!

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This video was created for educational purposes ONLY. It does not constitute or replace any medical advice - if you have any health queries please consult your healthcare professional.

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