In the 21st century, as Earth faces a dire overpopulation problem, humanity seeks refuge on Mars. But to make the red planet habitable, they must first transform its harsh conditions. To kickstart the process, they send moss and hardy creatures like cockroaches. Fast forward to 2597, where fugitives Komachi and Nanao dodge Tokyo's relentless police pursuit. A flying car piloted by Dr. Honda intervenes. Honda's mission is clear: eliminate the cockroaches on Mars. Seeing potential in the criminal duo, he offers them a deal – eradicate the Martian roaches, get rewarded handsomely, and erase their past crimes.
However, there's a catch – they must undergo a risky surgery. Initially hesitant, Komachi eventually agrees to the procedure to be with Nanao. Two years later, they're on the spaceship BUGS2 with a diverse crew heading to Mars. A spar between Jin and Komachi ends in a draw, and Jin tries to make a move on Nanao but is rejected. Ichiro scoffs at the idea of this being freedom. As Lee munches on some creepy crawlies, Tezuka sneaks up to Maria. He startles her by licking her hand, making Maria run to Osako for comfort and safety. The women pass by, catching the attention of Toramaru and Yoshikane. Asuka confronts them. Nanao reveals the shocking truth: Toramaru and Yoshikane are yakuza, Asuka's a corrupt cop, Tezuka's a serial killer, Maria's an illegal immigrant, Osako exploits teens, Ichiro's a hacker, and Lee is a terrorist.
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