bufotenin and 5-MeO-DMT
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Psychedelic frogs produce bufotenin and 5-MeO-DMT as active constituents of their venom. Both compounds have significant medicinal value—see the freely-accessible scientific references below for further information.
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DOI: 10.1177/0269881118769063 “The epidemiology of 5-methoxy- N, N-dimethyltryptamine (5-MeO-DMT) use: Benefits, consequences, patterns of use, subjective effects, and reasons for consumption”
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DOI: 10.1007/s00213-019-05236-w “A single inhalation of vapor from dried toad secretion containing 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) in a naturalistic setting is related to sustained enhancement of satisfaction with life, mindfulness-related capacities, and a decrement of psychopathological symptoms”
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DOI: 10.2174/138920010794233495 “Psychedelic 5-methoxy-N,N-dimethyltryptamine: metabolism, pharmacokinetics, drug interactions, and pharmacological actions”
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DOI: 10.1080/00952990.2018.1545024 “5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) used in a naturalistic group setting is associated with unintended improvements in depression and anxiety”
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The above-cited references and hundreds more free drug science articles can be accessed via my PubMed collection at xtalxlear.com (or just google the “DOI:” number or article title).
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Bufotenin, 5-MeO-DMT, serotonin, psilocybin, psilocin, and DMT are shown in green. Idealized coordinates for these compounds were obtained from PubChem. Human serotonin receptor 5-HT2a is shown in red and yellow. 5-HT2a receptor graphics were prepared using the 2.9Å x-ray crystal structure (PDB accession code 5TVN) reported in DOI: 10.1016/j.cell.2016.12.033. Molecular visualizations were prepared using open source PyMOL.
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Original music by Andrew Smetek (@hisssnarl on Instagram).
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