In this Interview, Jean-Francois Tremblay, owner of CanLab and I dig in to one of the new darlings of the peptide world - Tesamorelin and a less known but possibly just as effective other option - Setmelanotide - an offshoot of the better known Melantonan 2. We also cover AOD 9604, FRAG 17691 and CJC1295 ...and why you probably want to avoid the version with DAC (drug affinity complex)...
We start with a chat about how if you're after lasting results there's really no way to avoid optimizing your diet, moving more, optimizing sleep etc... but these peptides might just help to speed things along and ease some of the bumps along the way.
Show Notes:
8:30 Keto Calorie Math
10:00 Peptides Help with Fat Loss Body Recomposition
Growth Hormone unregulated by Fat Loss peptides like FRAG 17691 or AOD9604 (just one amino acid difference) help to mobilize fatty acids in the fat cell – but need to be in calorie/energy deficit for it to stay out
11:30 Consistency and sticking to your plan is the ultimate secret sauce…
12:40 Why Canlab combines Frag and AOD 9604 More about Frag and AOD….are they the same or different? AOD lacks one tyrosine…means that it lasts longer…whereas Frag uses more up front and gets metabolized faster…..
15:45 Tesamorelin…..what it does….
18:16 The skinny on Tesamorelin….it’s not about Tesa it’s about the growth hormone release….
19:00 Re Muscle Gains attributed to Peptides….in studies re old people it’s about bringing back muscle you once had…. Hormone replacement therapy is at the foundation of reclaiming muscle mass
GH good for muscle sustaining (vs growth) and tissue repair (but doesn’t hold a candle to BPC and TB4)
24:18 Tesamorelin – origins – where it came from originally….very close to CJC 1295 (Mod IGRF 121 is actually CJC 1295 without dac). and other Growth Hormone Secretagogues….
27:13 the difference between Tesa and CJC not really all that great….why some people may be promoting Tesa over CJC 1295 the magic is in the dose….
28:15. Difference about with Dac and without Dac
29:00 with Dac too many peaks of growth hormone (similar to MK 677….increases risk of insulin resistance…..why is the Dac long lasting…binds to albumin in the blood ….which is problematic as there may have been relationship to blood cancer seen in certain studies….so better to use without DAC…just use multiple times a day if necessary
30:45 Post workout (3) is a good time…but pre bed(1), pre workout and first thing in the morning (2) are all better
33:35 Setmelanotide – another derivative of alpha MSH (Melanotan, melanotan 2, PT141)
Basically prioritizes appetite suppression over tanning and sexual enhancement..they all create a tan just to varying degrees….
SM get appetite curbing (some sexual stim)…increases metabolic rate by about 6%, without increasing HR or BP….
On average can expect about 1 lb a week fat loss….
Many reports of people using it with good results – safe track record…..Clinical studies went for 12 months
39:20 Do not start at full dose of 1.5mg a day….start at .5 1-2 days then 1.0mg for a couple of days and then increase to full dose to avoid possible headache/nausea
In studies – they changed nothing else….and saw results but it’s likely that as people lost weight they may have started to move more etc…
43:47 At this point best method for most peptides is SubQ over oral….Intranasal may work but need to use higher dose (aka PT141 1 mg is SubQ and 2mg is IntraNasal)
45:09 Tesofensine – not a peptide acts on dopamine and AC receptors in the brain so needs to be used with great caution
Please note that this video is intended for information purposes only and is not intended to substitute professional medical advice, diagnosis or treatment. Peptides are for the most part classified as research chemicals so should not be used on humans. Before changing your diet or using any new supplement make sure to consult with your health care provider. Always seek the advice of your physician or health care provider with any questions or concerns you may have regarding a medical condition.
