References/Resources: [ Ссылка ]
In this part-3 and final video on eukaryotic DNA replication initiation, we discuss the process of origin firing. This is when cdc45 and GINS form the CMG helicase, which leads to pre-initiation complex formation. The CMG helicase marks the origin melting process. After melting the origin of replication, the CMG helicase forms the replisome, which can enter elongation. We dive into how all this is established and we also connect origin firing to the cell cycle dynamics as well.
Jump to your favorite section:
00:00 Outline
00:44 Starting the fire
02:12 DDK starts Firing
03:37 CMG Helicase forms
06:40 Origin Melts
08:55 Replisome assembly
11:55 Removing Histones
Patreon Page: [ Ссылка ]
DNA Replication Initiation videos (Eukaryotes)
Part 1 (Origin Recognition): [ Ссылка ]
Part 2 (Origin Licensing): [ Ссылка ]
Complete DNA Replication playlist: [ Ссылка ]
*Must watch playlists*
All videos on DNA Replication: [ Ссылка ]
All videos on Transcription: [ Ссылка ]
All videos on Translation: [ Ссылка ]
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