Salmonella is colonizing the ceca. Thus, butyrate needs to be protected to have an effect against Salmonella through a clear anti-virulence effect by downregulating virulence genes. A large part of antimicrobial use is for intestinal disorders and coated butyrate supplementation shows a reduction in Necrotic enteritis (Clostridium perfringens) occurrence.
Butyrate is a key molecule for strengthening gut integrity, reducing gut inflammation and improving tight junctions. Lots of gut bacteria are butyrate producers helping promoting a better gut health and as feed supplement could further reduce necrotic enteritis and other gut dysbiosis. Cecal butyrate producing bacteria can be stimulated with dietary xylan-oligosaccharides which further increases cross-feeding lactate to butyrate using bacteria.


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