This T cell development lecture explains about the T cell maturation and differentiation pathway. It explains the mechanism of how T cell is trained in thymus after the activation and the chemical activation and differentiation of T cells in Thymus. This video also explains the thymic selection and clonal propagation of T cells.
Learn more about the T cell development with this immunology lecture here-
In addition to cell cycle proteins, cytokines and their receptors are produced following antigen activation of T cells. These are involved in the expansion and further differentiation of the T cells into memory and effector cells. IL-2 is an autocrine factor which leads to T cell proliferation. Other surface molecules induced following activation include CD40L (CD154) which interacts with CD40 on dendritic cells inducing them to produce cytokines (e.g. IL-12) required for T cell proliferation and differentiation into Th1 cells. This leads to the specific T cell priming and clonal expansion necessary for their effector function and the development of memory.
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