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Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry - a 2 minute Preview of the Experimental Protocol

Frederick A. Rubino, Yoon Hyeun Oum, Lakshmi Rajaram, Yanjie Chu, Isaac S. Carrico
Stony Brook University, Department of Chemistry;

Adenovirus particles are engineered to contain either the unnatural amino acid analogue azidohomoalanine or the azido sugar O-GlcNAz. The azide group of each is chemoselectively ligated via "click" chemistry reactions as a means of viral surface modification.

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