So you've likely heard of gene editing using approaches such as CRISPR-Cas9, but have you heard that we can also edit the epigenome?

In this video we'll discuss epigenetics and why this might be something you want to target (e.g to treat different diseases such as cancer & aging) and then look at how this can be achieved by modifying epigenetic marks such as methylation and acetylation.

So we can edit the epigenome, BUT there are many challenges ahead e.g delivery and designing the technology to achieve the desired outcome, but i think the tech is SUPER cool and something worth knowing about.

p.s whilst making this video i underestimated how much i could simplify it...this topic is HUGE.. so i will likely make a secondary video to explore this topic further when i get the time :D

TIMESTAMPS;
Intro - 00:00
Epigenetics - 00:40
Epigenome editing - 03:25
Challenges - 09:20

REFERENCES;
CRISPR Tools for Physiology and Cell State Changes [ Ссылка ]
Dominguez, A., Lim, W. & Qi, L. Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation. Nat Rev Mol Cell Biol 17, 5–15 (2016). [ Ссылка ]

Check out @LifeXtenShow latest video - [ Ссылка ]

Icons in intro; "[ Ссылка ] vector created by freepik - www.freepik.com

свернуть