In this Research Spotlight episode hosted by our Editorial Board member Adrián Luguera Ruiz, Dr. Sarah Hejnosz joins us to share her work on cycloadditions with tertiary amine N-oxides and silyl imines.

This episode also has an affiliated problem set available, which is available on our project homepage at synthesis-workshop.com.

Key reference:
Organic Letters 2023, 25 (25), 4638-4643.
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Additional references (in order of appearance):
1) Hung, D. T. WO2009135091A1, 2009; 2) Nickolson, V. J. et al. Journal of Pharmacy and Pharmacology 1981, 33 (1), 760-766; 3) Daly, J. W. et al. Natural Product Reports 2000, 17 (2), 131-135.
1) Roussi, G. et al. Canadian Journal of Chemistry 1985, 63 (3), 725-734. 2) Davoren, J. E. et al. Synlett 2010, 2010 (16), 2490-2492.
1) Chen, Z.; et al. Angew. Chem. Int. Ed. 2022, 61 (47), e202212160; 2) Guram, A. S.; et al. Angew. Chem. Int. Ed.1995, 34 (12), 1348-1350; 3) Chang, Z.et. al. Nature Communications 2021, 12 (1), 4342; 4) Hesp, K. D. et al . Org. Lett. 2012, 14, 2304.
Neal, M. J.; Hejnosz, S. L. et al. J. Org. Chem. 2021, 86 (17), 11502-11518.
Roussi, G. et al. Heterocycles 1992, 34 (2), 293-301.
1) Vrudhula, V. M. et al. US20160016967, 2016; 2) Singh, A. K et al. WO2019089066, 2019; 3) Roy, J. An Introduction to Pharmaceutical Sciences: Production, Chemistry, Techniques and Technology; Elsevier Science, 2011.
1) Kondaparla, S. et al. RSC Advances 2016, 6 (107), 105676-105689; 2) Wixey, J. S.; Ward, B. D. Chemical Communications 2011, 47 (19), 5449-5451.
1) Lee, B. J, et al. Organic Letters 2022, 24 (30), 5513-5518; 2) Wang, C.; et al. Organic Letters 2022, 24 (35), 6455-6459.
1) Karaali, N., et al. Journal of Heterocyclic Chemistry 2020, 57 (4), 1806-1815; 2) Wolfe, J. P. et al. The Journal of Organic Chemistry 2000, 65 (4), 1158-1174.

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