Factor V Leiden is the most common inherited thrombophilia blood disorder.

Factor V Leiden mutation is an inherited condition associated with an increased risk of developing blood clots. This mutation makes it more difficult for your body to turn off the blood clotting process.

Factor V Leiden is seen in about 5 percent of Caucasians who do not have a family history of thrombosis and approximately 20 percent of patients who present with their first episode of venous thromboembolism.

A small prospective study indicated that the annual risk of recurrent thrombosis in a patient who is heterozygous for factor V Leiden was approximately 7.5 percent.

The lifetime risk of venous thrombosis in patients who are heterozygous for Factor V Leiden is approximately 10 percent. This may be increased if there is a strong family history of thrombosis with multiple family members having episodes of thrombosis.

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