Macrolide antibiotics such as Erythromycin, Clarithromycin, Roxithromycin, Azithromycin etc exert their antibacterial effect by inhibiting bacterial protein synthesis. They bind at P site of 50s ribosome of bacteria and block the translocation of peptidyl t RNA as well as block the elongation tunnel( situated at P site) through which newly formed peptide emerges after peptide bond formation,
MACROLIDE ANTIBIOTICS (Part-3): Mechanism of Action
Теги
macrolide antibioticerythromycinroxithromycinclarithromycinflurithromycinmechanism of actionantibioticsantibacterial agentsgram positive bacteriagram negative bacteriabacterial protein synthesistranslationtranslocationelongationinhibition of bacterial protein synthesisribosome30s ribosomes50s ribosomeA siteP siteE siteinitiation complexm RNAt RNAtetracyclineaminoglycosidesstreptomycinneomycingentamicinkanamycinamikacinchloramphenicol
