This Resident Evil 3 Remake game guide video shows how to defeat Nemesis Stage 2 in the NEST 2 facility. The boss battle takes place in a large round area and Nemesis is again a strong four legged creature. Make sure to take plenty of ammo for the magnum, grenade launcher and shotgun for this battle, as well as some healing items.
The first part of the boss fight is easy - just keep using your grenade launcher. Second part will commence after Carlos shows up. Listen to his tips on where Nemesis is hiding (tank number) and shoot at the correct red button(s) to electrocute Nemesis. He'll be lying defenselss on the ground so use a Magnum to quickly weaken him.
You must watch out for all of the boss's melee attacks, as well as for big jumps towards Jill. Standard zombies will be showing up later on. Don't let them surprise you and consider using a grenade launcher to harm both Nemesis and a zombie standing next to the boss. Keep fighting until a cut-scene starts showing your win.
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