Autoimmunity causing B12 deficiency.
Megaloblastic anemia is a form of anemia characterized by very large red blood cells and a decrease in the number of those cells.
1. Acquired deficiency in B12 and Folic Acid/Folate.
**B12 depletion and/or absorption issues with Metformin, Colchicine, PPI, Histamine 2 Receptor antagonist and alcohol.
**Vegans and vegetarians.
Types of B12
Natural forms: methylcobalamin, hydroxycobalamin, adenoslycobalamin
Synthetic form: cyanocobalamin
2. Pernicious anemia is a type of megaloblastic anemia. Autoimmune conditions related to intrinsic factor antibody, parietal cell antibody and receptors for intrinsic factor.
Intrinsic factor and HCL are produced by the parietal cells
Chief Cells produce pepsinogen and pepsinogen is converted to pepsin in the presence of HCL.
B12 can be absorbed by diffusion when there are adequate amounts of B12. Or they can be transported by intrinsic factor to the ileum for absorption.
Different B12 delivery methods for Pernicious Anemia
B12 intramuscular injections
Sublingual B12
Transdermal B12
Testing:
Parietal Cell antibody
Intrinsic Factor antibody
MCV
Homocysteine
Methylmalonic acid
Dr. Jin Sung is a Chiropractic Physician who specializes in the management of complex chronic conditions in Massachusetts, 30 minutes north of Boston. He utilizes natural and alternative therapies to help manage complex cases such as Hashimoto's, autoimmune conditions, IBS, SIBO, chronic fatigue, brain fog, early Alzheimer's, etc.
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The content of this video is for educational purposes only and does not constitute medical advice. Please consult with your physician before embarking on any dietary changes or taking any nutritional supplements.
