This a review of a piece I read by David Nield in the Medical Express magazine, where he describes a study published in Nature Communications, which postulates that human lifespan tops out at 150.
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• This new research looks into the idea of biological aging or senescence, this relates to the speed at which our bodies deteriorate, which may or may not match our chronological age, which as David Sinclair says, ‘it is the number of times the earth has gone around the sun.’ and is not a good measure of health
• Scientists have now developed a new way to interpret fluctuations in the numbers of different kinds of blood cells we have, this new measurement technique is called the Dynamic Organism State Indicator or (DOSI).
• Over time, the DOSI score shows the body’s resilience slowly dropping – which is one of the reasons it takes longer to recover from disease and injury as we age
• The researchers say that assuming we can avoid general disease and disaster throughout the course of our life, DOSI is a reliable method for showing when that resilience would give out completely and we would expire
The researchers explain in their paper that "Extrapolation of this trend suggested that DOSI recovery time and variance would simultaneously diverge at a critical point of 120-150 years of age corresponding to a complete loss of resilience."
• Blood cell count information on more than half a million people taken from research databases in the UK, the USA, and Russia was analyzed, along with step-count data on 4,532 individuals to measure the rate of peoples decline in fitness
• Blood cell count could point to a range of problems in the body. To ensure it was a good general indicator of all-around health and recovery, the team used the step-count data to double-check their rational
• Another discovery made from the data was a shift in the aging trajectories from age 35 and upwards, and then again from 65 and upwards, this matches up with some society markers, such as the age when people tend to retire from elite sport and the age when people usually retire from full-time work.
• The researchers said that in the future the study could be used to inform treatments that can target diseases and illness without affecting biological resistance, and perhaps one day even extend the current maximum lifespan of 122
• At the time of this study, the oldest age anyone has ever reached on record is 122 years and 164 days, by Jeanne Calment, this new analysis is generally in line with previous studies that have mentioned a maximum lifespan for humans of around 120-140 years. The study theorizes that without some pretty radical changes to our bodies at a fundamental level, it would be very hard to squeeze many more years out of our fragile forms
The researchers concluded that "The criticality resulting in the end of life is an intrinsic biological property of an organism that is independent of stress factors and signifies a fundamental or absolute limit of human lifespan."
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