The Institute for Neuro-Immune Medicine conducted its monthly Research Seminar Series for March 2024. Marzieh Eini Keleshteri, Ph.D., with her mentor Prof. Benedict C. Albensi, presented her research entitled “Advanced Modeling of Bioenergetics in the Mitochondrial Electron Transport Chain with Emphasis on Complex IV”.

The study aims to provide a computational model of Complex IV in the mitochondria and its underlying principles and insights it provides into the mitochondrial function.

As the primary organelles responsible for generating ATP, dysfunctional mitochondria are implicated in various neurodegenerative disorders, metabolic diseases, and even aging. Using advanced mathematical modeling, they reveal the significance of understanding the mitochondrial function in various physiological and pathological processes and eventually unveil its application for predicting Alzheimer’s Disease.

Key Points in This Episode
00:00 Introduction
04:28 Mitochondrial structure and function
08:00 The objectives of the research
09:31 What is an electron transport chain (ETC)?
10:29 The role of complex IV in Mitochondrial Respiration
11:54 Importance of OCR measurement
15:21 Perturbing Bioenergetics
17:41 Advancements in modeling mitochondrial function
19:12 The experimental data and mathematical model used
22:56 Overview of the model calibration process
27:07 The model interface, its robustness, and GUI
33: 55 Conclusion and future application
36:22 Application for Predicting Alzheimer’s Disease
37:41 Recognition and acknowledgement

Dr. Marzieh Eini Keleshteri is a distinguished researcher with dual M.Sc. degrees in pure and applied mathematics and computer sciences, as well as Ph.D.s in Mathematics from the University of Isfahan, Iran, and Eastern Mediterranean University, North Cyprus, and in Electrical and Computer Engineering from the University of Manitoba, Canada. Her expertise lies in applying Machine Learning to model cancer incidence rates and innovating non-invasive microwave imaging for high-resolution reconstructions. Currently a postdoctoral fellow at St. Boniface Research Centre, University of Manitoba, she contributes to advancing computational models for mitochondrial function, with a focus on Alzheimer's disease predictions. Dr. Keleshteri's leadership extends to roles in IEEE Canada, including the R7 Women in Engineering committee and WIE Winnipeg section, highlighting her commitment to interdisciplinary research.

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Prof. Benedict C. Albensi is a distinguished researcher and leader in the field of neuroscience. Currently serving as a prominent figure at the St. Boniface Research Centre, University of Manitoba, he focuses on advancing our understanding of Alzheimer's disease. With a wealth of experience and expertise in neurobiology and computational modeling, Prof. Albensi is dedicated to unraveling the complexities of brain function and pathology. His impactful contributions extend to leadership roles, and he is recognized for his commitment to pushing the boundaries of knowledge in neuroscience.
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