The most commonly used treatment for urticaria and angioedema is antihistamines. Antihistamines block the effect of the histamine that is released and reduce the itching and rash in most people. If the urticaria occurs frequently then the antihistamines are best taken regularly as they are much better at preventing attacks than reversing them. Very rarely injections of adrenaline (epinephrine) may be required if there are breathing problems caused by urticaria and angioedema

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