Super-resolution microscopes reveal that transcription factors are not always bound to their binding sites on DNA. Use this amazing animation in your classroom to show cutting-edge science at work!
Eric Betzig of HHMI’s Janelia Research Campus was awarded the 2014 Nobel Prize in Chemistry for developing a technique for visualizing molecules with a precision of 2-25 nm. The method has allowed tracking the behavior of single protein molecules in a living cell. This animation was developed using single-molecule tracking data, showing a representation of how transcription factors locate their appropriate binding sites on DNA. They spend most of their time floating around the nucleus, or "sampling" DNA sequences—represented in the animation as a rapid spiraling motion around the DNA molecule.
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