Presented By: Stacey Ward, PhD
Speaker Biography: Stacey received her Ph.D. in Microbiology and Immunology from SUNY Upstate Medical University in Syracuse, NY, studying the dysregulation of cell cycle proteins by varicella zoster virus. After completing a postdoc at University of Connecticut Health Science Center investigating herpes simplex virus DNA replication, she moved to St. Louis for a second postdoc at the Washington University in St. Louis School of Medicine dissecting the role of sonic hedgehog signaling in brain cancer. She joined MilliporeSigma in early 2016 as a member of the Cell Design Studio, a team focused on developing genetically engineered custom cell lines. She developed our current off-the-shelf tumor associated antigen panels and the monoallelic HLA cell lines, and currently leads a team of scientists.
Webinar: Genetically-Engineered Immuno-oncology Cell Lines and Services for Early Drug Discovery Research and Preclinical Manufacturing
Webinar Abstract: Gene editing experts within MilliporeSigma’s Cell Design Studio™ provide premier custom cell line engineering services to create and deliver unique cell-based assays tailored for drug discovery and preclinical manufacturing. Our cellular models have been used for applications such evaluating efficacy of CAR-T cells, screening candidate checkpoint inhibitors, and generating potency assays for therapeutic testing. We have also generated new functional biologically-relevant tumor-associated antigen and monoallelic HLA panel cell lines that express either individual tumor antigens at varying levels or individual HLAs. In this presentation, we will discuss the technology of these lines, their utility in immuno-oncology and novel therapeutic testing, and how they can fit in your workflow.
Learning Objectives:
1. Understand the limitations of cells commonly used in immuno-oncology assays
2. Learn about engineered tumor-associated antigen cell panels
3. Gain insight into the benefits of mono-allelic HLA expressing cell lines
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