Zebrafish robustly establish a 50 : 50 ratio of arteries and veins that occupy the spaces between segments along the animal's trunk. Although intersegmental vessels (ISVs) are originally all arterial, it is thought that they can be remodelled into veins by secondary sprouts from the posterior cardinal vein. In their study, Holger Gerhardt and colleagues now investigate how this artery-vein specification process is regulated.

Their paper includes some beautiful spinning disc confocal live imaging of the process of vascular remodelling in normal and mutant conditions. We've collated some of them here.

Check out their full Open Access paper at:
[ Ссылка ]

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