Thomas B. Casale, MD - FARE Medical Advisor at Food Allergy Research and Education (FARE)
Professor of Medicine and Pediatrics Division of Allergy/Immunology at University of South Florida ,Tampa, FL

What about allergic reactions?
Pfizer’s most extensive safety trials showed allergies to the vaccine to be extremely rare (about 0.1%, or one per thousand, greater than the placebo: 0.63% vs. 0.51%). However, the clinical trials excluded individuals with a history of severe adverse reaction associated with a vaccine and/or severe allergic reaction (e.g., anaphylaxis) to any component of the study intervention(s). Out of thousands who received the vaccine on the United Kingdom’s first day of vaccinations, two people had allergic reactions from which they recovered. Both individuals had a history of severe allergic reactions in the past and carried epinephrine autoinjectors. At this time, it is not known whether these reactions can be attributed to the vaccine. It is important to remember that such reactions can happen with any vaccine or drug. Whether this will affect U.S. labeling and precautions for people with severe allergies will likely be determined during FDA deliberations. However, it is important to note that these vaccines do not contain egg, so there are no elevated specific risks for egg-allergic individuals.

What is in the mRNA vaccines besides mRNA?

The main ingredients in mRNA vaccines are:
- An adjuvant, which stimulates the immune system to react more vigorously and increases the likelihood that the body will recognize the spike protein as “foreign,” is often contained in vaccines. Adjuvants are generally safe but designed to promote an inflammatory/immunologic response. The adjuvant is what causes most of the side effects that result from the vaccine including fever, headache, and pain and soreness in your muscles. So, these side effects are a sign that the vaccine is doing what it is supposed to. The Pfizer vaccine does not contain an adjuvant.
- Lipid (fat) and cholesterol nanoparticles (very small in size) that hold the mRNA and deliver it to muscle cells that use the mRNA to make the spike protein.
- Salts and sucrose (sugar).

!! There is no egg, mercury, preservatives or other foreign ingredients. In summary, the ingredients in the Pfizer vaccine are all found in your body at lower concentrations.

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