The MPNRF Interferon (IFN) Initiative is a multi-center project that has brought together internationally recognized experts in both blood and solid tumors to determine how cytokine-driven pathways affect the trajectory of the MPNs, a closely-related group of progressive blood cancers. The collaboration among this group of scientists speaks to their drive to answer these questions:
-How and why does targeting the IFN pathway reduce the burden of mutated stem cells in MPN patients?
-Why is targeting this pathway effective for some MPN patients but not others?
-Why are the positive effects of targeting this pathway not permanent?
