Hanny Al-Samkari, MD, Massachusetts General Hospital, Boston, MA, highlights recent developments in pyruvate kinase activators to treat pyruvate kinase deficiency (PKD) and diseases of hemolysis and ineffective erythropoiesis including myelodysplastic syndromes (MDS), commenting on mitapivat and AG946. This interview took place at the 64th ASH Annual Meeting and Exposition congress in New Orleans, LA.

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