Lesson on Acute Tubular Necrosis (ATN): Symptoms, Causes and Treatments. Acute Tubular Necrosis (ATN) is an abrupt decrease in GFR with increases in urea and creatinine levels due to ischemic or nephrotoxic injuries to renal tubules. ATN results in high FeNa and excretion of "muddy brown casts". The two main categories of causes of ATN are toxins, which can be due to antibiotic, antiviral, chemotherapies, IV contrast, bacterial endotoxins, myoglobin, and ischemic causes such as shock, hypotension, decreases in circulating volume or decreases in delivery of volume (heart failure). Treatment includes correcting the underlying cause, removing nephrotoxins and identifying high risk patients to prevent ATN in the future.


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**MEDICAL DISCLAIMER**: JJ Medicine does not provide medical advice, and the information available on this channel does not offer a diagnosis or advice regarding treatment. Information presented in these lessons is for educational purposes ONLY, and information presented here is not to be used as an alternative to a healthcare professional’s diagnosis and treatment of any person/animal.

Only a physician or other licensed healthcare professional are able to determine the requirement for medical assistance to be given to a patient. Please seek the advice of your physician or other licensed healthcare provider if you have any questions regarding a medical condition.

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