This animation explains about the mechanism of action of tetracycline antibiotics. Tetracycline antibiotics inhibit the initiation of translation by binding to the 30S ribosomal subunit, and preventing aminoacyl-tRNA from binding to the mRNA translation complex.
(Reference)
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Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors. PNAS July 19, 2016 113 (29) 8188-8193; published ahead of print July 5, 2016
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Interaction of antibiotics with functional sites in 16S ribosomal RNA
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The impact of aminoglycosides on the dynamics of translation elongation. Cell Rep. 2013 Feb 21;3(2):497-508.
10. 16S ribosomal RNA U1052 and C1054
Alexis I. Cocozaki, Roger B. Altman, Jian Huang, Ed T. Buurman, Steven L. Kazmirski, Peter Doig, D. Bryan Prince, Scott C. Blanchard, Jamie H. D. Cate, and Andrew D. Ferguson
Resistance mutations generate divergent antibiotic susceptibility profiles against translation inhibitors. PNAS July 19, 2016 113 (29) 8188-8193; published ahead of print July 5, 2016
Tetracycline: Mechanism of action 【USMLE, biochemistry】
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