A cell with chromosomes that have extra or fewer copies is called aneuploid. According to scientist Rong Li, aneuploidy is the #1 hallmark of cancer and is found in more than 90% of solid tumor cancer types. In a bid to find a potential weak spot among aneuploid cancer cells, Li and her team at Johns Hopkins found two proteins in yeast called ART1 and Rsp5 that regulate the cells’ ability to draw in nutrients such as glucose and amino acids. When the scientists inactivated these proteins in the aneuploid yeast cells, they lacked the proper intracellular nutrient levels and were less able to grow. This video shows aneuploid yeast cells on the left and normal, haploid cells on the right. The aneuploid cells on the left have difficulty drawing in the fluorescent molecules. Whereas, the normal yeast cells on the right are able to rapidly draw them in. #AneupliodCells #JohnsHopkins
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