Basically - know when to dodge his attacks.
Difficulty used during this video: Nightmare

Items used under the boss:
1 Lightning Hawk + Long Barrel
1 Samurai Edge (Not entirely necessary)
60x 9mm Handgun Ammo (Not entirely necessary)
27x MAG Ammo
4x Red + Green Herb Healing Item
4x First Aid Spray
2x Assault Coins (Does not make a difference as the spores are one-hit with the Lightning Hawk on any difficulty)
1x Chris Redfield CQC S.T.A.R.S Book

The essential part of winning over this boss is by comprehending his 5 different attacks and learn how to counter them by dodging them. The Lightning Hawk plays an important part of this aspect due to it one-hitting spores without any difficulties, but the G18 Burst is also a good alternative. The CQC Book allows you to dodge his attacks easier and therefore you will beat this boss in 1 2 3! :D

Speaking of the Lightning Hawk, you can get it right after meeting up with the U.B.C.S squad. It should be normally where you get your first green herbs laying on a bunch of crates in the subway station. This only counts for the higher difficulties (Nightmare and Inferno).

You may probably ask, how did you get so many MAG ammo? Well, I gathered a lot of high-grade gunpowder throughout the game and spared up until the final boss.

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