The series 100th episode, titled Point of No Return will air on Thurs., 4/15 at 9:00 p.m. ET/PT on The CW.

A frustrated and exhausted Dean (Jensen Ackles) begins to think the only way to stop Lucifer and save the planet is to say yes to becoming Michaels vessel, but unbeknownst to him the angels have been coming up with a Plan B. Dean, Sam (Jared Padalecki), Castiel (Misha Collins) and Bobby (guest star Jim Beaver) are horrified at the angels' new idea and take on Zachariah (guest star Kurt Fuller) to prevent the beginning of the end on Earth. Also guest stars Jake Abel as Adam. Phil Sgriccia directed the episode written by Jeremy Carver.

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