Appleton is a city in Outagamie, Calumet, and Winnebago counties in the U.S. state of Wisconsin. One of the Fox Cities, it is situated on the Fox River, 30 miles (48 km) southwest of Green Bay and 100 miles (160 km) north of Milwaukee. Appleton is the county seat of Outagamie County. As of the 2020 Census it had a population of 75,644, making it the sixth largest city in Wisconsin. Appleton is a part of the Fox Cities metropolitan area, the third largest in the state behind Milwaukee and Madison.

Appleton serves as the heart of the Fox River Valley, which is home to Lawrence University, the Fox Cities Exhibition Center, Fox Cities Performing Arts Center, Fox River Mall, Neuroscience Group Field at Fox Cities Stadium, Appleton International Airport, and the Valley's two major hospitals: St. Elizabeth Hospital and ThedaCare Regional Medical Center–Appleton. It also hosts regional events such as Octoberfest and the Mile of Music.
Following the Flint water crisis, a report of Wisconsin Rust Belt cities showed high levels of lead contamination in the water of Appleton, with children under the age of 1 testing positive for lead. With a state average of 1.9 per 100 for this age group, Appleton tested at 4.5 per 100 for the same age group.
Significant annexations to the city, taken from the Town of Grand Chute, were performed in the next two decades. The first, the "Glendale" district, was completed on November 8, 1941, growing Appleton north past Glendale Avenue. Another became official on December 22, 1950 after multi-year disputes, when the unincorporated villages of Bell Heights and Whispering Pines were annexed into the city from Grand Chute. Bell Heights added new area to the northwest edge of Appleton, and Whispering Pines, to the northeast, would include land where Appleton Memorial Hospital would later be built. Bell Heights and Whispering Pines increased the population of the city by ten percent, and its area by twenty percent, overnight.

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