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Tricyclic antidepressants are a class of mental health drugs recognizable by their endings of -triptyline: like amitriptyline and nortriptyline, as well as -pramine: like clomipramine, imipramine, and desipramine. The only exception to these 2 endings is doxepin. As a class, all the TCAs are used to treat depression, as well as nerve pain from causes like diabetic neuropathy or fibromyalgia. Important side effects include orthostatic hypotension which can result in dizziness and falls, and anticholinergic effects like dry mouth, urinary retention, tachycardia, and so on. Finally, tricyclic antidepressants are lethal in overdose.

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