Calorie restriction (CR) is the chronic reduction of total calorie intake without malnutrition and this can range from 20-40%. CR has been shown in many different model organisms to extend lifespan and these effects appear to get more modest the closer the species is to humans.

But, how effective is it in humans and are there any safety consequences? Well, in this video I take a look at some recent data published from the CALERIE trial, a 2-year study where human patients underwent on average a 14% CR. In particular they focus on immune system aging such as the thymus and identify the gene PLAG2G7 as an interesting target to follow-up.

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TIMESTAMPS:
Intro - 00:00
Caloric Restriction (benefits & risks) - 00:32
Human data - 03:15
Latest human data - 04:30
Thoughts - 06:30

References:
Caloric restriction in humans reveals immunometabolic regulators of health span - [ Ссылка ]

Please note that The Sheekey Science Show is distinct from Eleanor Sheekey's teaching and research roles at the University of Cambridge. The information provided in this show is not medical advice, nor should it be taken or applied as a replacement for medical advice. The Sheekey Science Show and guests assume no liability for the application of the information discussed.

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