A sulfonamide diuretic that has similar physiological properties to thiazide diuretics, but does not have the chemical properties of a thiazide, lacking the benzothiadiazine molecular structure.

According to their molecular structure, thiazide diuretics can be divided in thiazide-type and thiazide-like diuretics.
Thiazide-like diuretics are superior to thiazide-type diuretics when thiazide treatment is considered for hypertension without increasing the incidence of hypokalemia, hyponatraemia, and any change of blood glucose and serum total cholesterol.
(Advantages of thiazide-like diuretics over thiazide-type diuretics)
• Longer elimination half-life
• Less cardiovascular risk

(Examples sulfonamide thiazide-like diuretics)
• metolazone
• chlorthalidone (CTDN)
• indapamide

(Examples sulfonamide thiazide diuretics)
• chlorothiazide
• hydrochlorothiazide

(Examples of sulfonamide loop diuretics)
• furosemide
• bumetanide
• torsemide

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