Time-lapse imaging of zerbrafish embryos developing under microperfusion on a Zebrafish Living Embryo Array technology.
The innovative technology has been designed for high throughput Fish Embryo Toxicity Tests (FET, OECD TG 236) in chemical risk assessment and aquatic ecotoxicity testing as well as drug discovery applications. The technology is fabricated in biocompatible, optically transparent polymer PMMA. It supports hydrodynamic immobilization of large numbers of zebrafish embryos suspended in a continuous microfluidic perfusion as a means of toxicant delivery
The modular system can be used in low and high-throughput applications. For the latter we pioneered a high density embryo array system that features 12 independent modules with a total of 252 zebrafish embryo cages. Its layout matches the one of standard 96-well plate enabling seamless integration with automated microscopy and imagining cytometry systems.
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