Patients whose blood cells don’t work correctly can be cured by receiving blood-cell-producing bone marrow from a healthy person via a bone marrow transplant. Unfortunately, the patient’s new bone marrow can attack his or her body, causing a potentially life-threatening condition called graft-vs-host disease. Natalia Schneider Nunes, a postdoctoral research fellow in the Intramural Research Program at the National Institutes of Health, studies a treatment for this illness called cyclophosphamide in the hopes that better understanding how it works can make bone marrow transplants safer and more effective.
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