There are several medications out there that are designed to slow the progression of Alzheimer's Disease. Learn a bit about how they work, what families think about their effectiveness and my opinion on them, too.
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A bit more detailed information about Donepezil and Memantine:
Donepezil or Aricept is what’s known as a cholinesterase inhibitor. When a person is suffering from Alzheimer’s disease, they begin to have less and less of a neurotransmitter called acetylcholine who’s job is to carry signals from nerve cells to muscle cells. Acetylcholine plays a vital role in muscle contractions, memory, motivation, sleep and learning. The brain also has an enzyme called acetylcholinesterase. This is the enzyme that helps to break down acetylcholine so that it can be recycled and rebuilt into new neurotransmitters for the next message.
So, the rationale behind Donepezil is relatively simple: if you block the enzyme acetylcholinesterase from breaking down the acetylcholine, then more of it will remain and the brain can continue carrying signals between nerve cells and muscle cells.
Memantine is what’s known as an NMDA antagonist. So, instead of the neurotransmitter acetylcholine, Memantine works by slowing the transmission of a different neurotransmitter called glutamate. Glutamate is the major excitatory neurotransmitter in the central nervous system. It plays an important role in learning and memory. But, it is thought that too much stimulation by glutamate may over-excite nerve cells and cause them to die. So, by blocking the effects of glutamate, Memantine may protect nerve cells from getting overstimulated.
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🙋 Answer to Cryptogram: It may be worth it to try and see if these medications can help them "be"
00:00 Intro
02:07 Donepezil (Aricept)
03:22 Memantine (Namenda)
04:44 Dementia Medication Effectiveness
