(brexanolone, 3α,5α-Tetrahydroprogesterone, 3α,5α-THP)

An endogenous inhibitory neurosteroid and acts as a positive allosteric modulator of the GABAᴀ receptor.
It is a pregnane (C21) steroid made from progesterone.

It has antidepressant, anxiolytic, sedative, analgesic, anticonvulsant, rewarding, prosocial, prosexual effects, and so on.
It is used to treat postpartum depression.
Side effects may include dry mouth, hot flashes, sleepiness, sedation, and loss of consciousness.

Cf. alprazolam

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