How does SGLT2 Inhibition Improve Heart Failure?
Different ways by which SGLT2 inhibition can improve heart failure are:
Natriuresis
Osmotic diuresis
These in turn leads to reduction of plasma volume and preload. An associated decrease in blood pressure, after load and arterial stiffness follows. Reduction in afterload can improve subendocardial blood flow as well.

свернуть