#drnajeeb #medicaleducation #pharmacology #betablockers #calcium

Calcium Channel Blockers in Hypertension🫀

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▬▬▬▬▬▬▬▬▬▬ Contents of this video ▬▬▬▬▬▬▬▬▬▬
00:00:00 Introduction
00:00:09 How Calcium Channel Blockers work?
00:01:02 L type Calcium Channel
00:04:23 Diltiazem, Verapamil, Nifedipine

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What are calcium channel blockers?
Calcium channel blockers are a group of medications that limit how your body uses the essential mineral calcium. Because your heart and circulatory system need calcium to function, these medications treat high blood pressure, heart rhythm problems and more.

How do they work?
Calcium is an electrolyte, which means it has a positive charge when it’s dissolved in water. Your body uses ions (atoms with an electrical charge) in electrolytes to transport things into and out of your cells. Your body is always working to balance things out. That means when calcium ions enter a cell, sodium ions leave, and vice versa.

Those ions enter and exit your cells using channels, which act just like doorways to the inside of your cells. Those channels also have a type of security feature, which only allows ions that have the right type of charge (either positive or negative) and the right size to enter and exit.

Calcium channel blockers take advantage of the fact that certain types of calcium channels tend to exist only in certain parts of the body. This allows targeting of medications depending on which channels they affect.

There are many calcium channels on each of the cells in question. At the right dosage, calcium channel blockers (sometimes calcium channel antagonists) only block some — but not all — of them. That slows down those cells’ use of calcium because there are fewer ways to bring it inside.

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