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Excitation Contraction Coupling in Smooth Muscles:
The calcium for smooth muscle contraction, comes from extracellular fluid, as well as sarcoplasmic reticulum.
Inside the cell, the calcium binds with calmodulin, and then this calcium-calmodulin complex activates myosin light chain kinase.
This enzyme phosphorylates the regulatory light chain of myosin, which restore the ATPase activity of the myosin head.
This allows the myosin cross-bridge cycle, producing muscle contraction.
To reverse the process, the calcium is pumped back into the extracellular fluid, and sarcoplasmic reticulum.
This inactivates myosin light chain kinase.
And the phosphate from the regulatory light chain, is removed by myosin phosphatase.
Chapters:
00:00 Intro
00:19 Entry of Calcium in Cytoplasm
01:57 Calmodulin
02:23 Myosin Light Chain Kinase
03:01 Cross Bridge Cycle
03:30 Termination of Contraction
04:25 Summary
Dr Vipul Navadiya
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.
