Cortical organoids on Axion's multiwell MEA system.
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Neural/cortical organoids, also known as mini brains, have emerged as a promising new model for studying the human brain. A cortical organoid is a three-dimensional human stem cell-derived in vitro human brain model that can be studied in a dish. Over time, they can develop complex neural activity that can be similar to the network function present in human fetal brains. This similarity can offer novel therapeutic approaches to understanding gene expression, morphology and neural activity.
In this webinar Dr. Trujillio describes how the introduced NOVA1, an archaic version of a human gene into a pluripotent stem cell derived neural organoid. Using Maestro MEA technology, Dr. Trujillo and team are able to detect complex neural network function and compare the complex network activity of the human and archaic version of the human cortical organoids.
What is a multiwell MEA assay?
Axion’s microelectrode array (MEA), also known as multielectrode array, plates have a grid of tightly spaced electrodes embedded in the culture surface of each well. Electrically active cells, such as neurons, can be cultured over the electrodes. Over time, as the cultures become established, they form cohesive networks and present an electrophysiological profile. The resulting electrical activity, spontaneous or induced firing of neurons, is captured from each electrode on a microsecond timescale providing both temporally and spatially precise data.
