This is the best strategy for speed running El Gigante in Resident Evil 4 Remake. Make sure you level up your rifle as seen in the beginning of the video. Remember it's better to take a split-second longer to line up a shot, rather than to waste 2 seconds missing a shot. With this method you won't be wasting grenades, shotgun ammo, etc. You'll have plenty of rifle ammo or large resources, so don't be afraid to go ahead and blast him with the rifle.
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