Omega Boost takes place in the year 2099, wherein a Sentient computer program, Alpha Core, has practically taken over the world. The player character is Lieutenant Lester, the pilot of Omega Boost, one of a series of humanoid mecha. In the opening FMV cutscene (featuring live actors and computer generated backdrops in the style of Wing Commander and Command and Conquer), Lester is tasked with travelling to Alpha Core's "Time Shaft", a space cannon which allows things flying through it to fly to a pre-determined time, to go back to the time when ENIAC (the first general purpose electronic computer) was invented and swap out a defective vacuum tube which spawns the Alpha Core virus for a new one.The destruction of Manhattan and Tokyo by the computer system Alpha Core is announced via intercom, and Lester is called to board Omega Boost. Upon starting a new campaign, the player is delivered to Planet ETA, which houses the Time Shaft. The player is ordered to destroy the many orbital and planet-based defenses, presumably controlled by Alpha Core, in order to enter the Timeshaft and fix ENIAC.
The US version used "Fly" by Loudmouth as the opening song and "The Road" as the ending theme also by Loudmouth. The Japanese release used "Shade" by Feeder as the opening song and "Ismeel" as the ending theme by Dip in the Pool. The EU/AUS version used an updated version of "Dreamer" by Cast for both the opening and ending as well as the final boss.
