The Syracuse Orange traveled to Louisville to take on the Cardinals in ACC Football action, and the Cardinals won big, 30-0 at home. Quarterback Malik Cunningham led the Cardinals with 219 yards passing, a passing touchdown and a rushing touchdown. Wide receiver Tutu Atwell caught the lone touchdown pass for the Cardinals, and Braden Smith led Louisville with 7 receptions and 65 yards receiving. The Louisville defense recorded 3 sacks, scooped up 3 fumbles and had an interception in the win.
