Misoprostol is a synthetic prostaglandin E1 analogue, which is commonly used in combination with mifepristone for medically induced termination of pregnancy.
In addition, it is also used in the management of miscarriages, especially missed and incomplete miscarriages, and to treat postpartum uterine bleeding.
Misoprostol is usually a safe, and well-tolerated drug.
Mild adverse effects include the following.
Gastro-intestinal disturbances, such as abdominal pain, nausea and vomiting, and diarrhea.
Headache.
Hyperthermia.
Intermittent breakthrough bleeding.
Menstrual irregularities, or abnormal uterine bleeding.
Lethargy.
And vertigo.
Rare, moderate to severe adverse effects include the following.
Hypotension.
Sinus tachycardia.
Uterine rupture and cervical laceration.
Anaphylaxis.
Thrombosis, and pulmonary embolism.
Finally, misoprostol is contraindicated in any person who has a hypersensitivity to it.
Normal pregnancy, and previous cesarean section are the other 2 contraindications for misoprostol.
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