Original release date: 6/8/20

In this episode, Eileen White, Chief Scientific Officer at the Rutgers Cancer Institute, describes the fundamental role of autophagy in the maintenance of health and prevention of neurodegeneration, cancer, and other diseases. She also goes into detail about the paradoxical finding that autophagy may benefit an existing cancer cell and help it to survive—a discovery leading to new possibilities in cancer therapy. We also discuss fasting (and molecules that induce autophagy) and the critical need to decode the proper fasting “dose” in order to improve human health.

We discuss:
00:00:00 - Intro
00:03:40 - Eileen’s discovery that a specific oncogene blocks apoptosis
00:10:00 - Defining apoptosis and its role in cancer prevention
00:17:20 - How cancer cells use the autophagy pathway to survive
00:29:15 - Stressors that induce autophagy
00:32:45 - The importance of autophagy in the brain and liver
00:40:00 - The mechanisms that can trigger autophagy to support longevity
00:42:30 - Evidence for cancer treatment by blocking autophagy
00:46:45 - Types of cancer that are most autophagy-dependent
00:52:40 - The autophagy paradox
00:59:15 - Finding a molecular signal for autophagy
01:13:00 - Current knowledge gaps around fasting as a tool for longevity
01:22:15 - Rapamycin, metformin, and other molecules that may induce autophagy
01:32:50 - How to study fasting and exercise as longevity tools
01:36:45 - The Nobel Prize for autophagic research
01:38:25 - Eileen’s future areas of research
01:49:25 - A fasting strategy for Alzheimer’s disease prevention
01:51:30 - Future study of metabolism and autophagy

Show notes page: [ Ссылка ]

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About:

The Peter Attia Drive is a weekly, ultra-deep-dive podcast focusing on maximizing health, longevity, critical thinking…and a few other things. With over 30 million episodes downloaded, it features topics including fasting, ketosis, Alzheimer’s disease, cancer, mental health, and much more.

Peter is a physician focusing on the applied science of longevity. His practice deals extensively with nutritional interventions, exercise physiology, sleep physiology, emotional and mental health, and pharmacology to increase lifespan (delay the onset of chronic disease), while simultaneously improving healthspan (quality of life).

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