Food has varying effects on your medications. They can Reduce how much of the medicine is absorbed, they can INCREASE how much is absorbed or they can delay when the medication is absorbed.
Reduced absorption means you don't get as much of the medication into your bloodstream and therefore it may not work as well as expected. Increased absorption means that you can get more side effects once the medication reaches its peak concentration in your bloodstream. Delayed absorption means that it takes longer to have the desired effect. This becomes most important with the sleeping medications
Here is the list - you can download this as a handout.
Should take with food
lurasidone (Latuda®)
vilazodone (Viibryd®)
ziprasidone (Geodon®). Bioavailability decreased by 1/2
Should not take with food
Quetiapine XR (Seroquel®)– increases max concentration and therefore side effects
Zolpidem (Ambien®)– delays absorption
Eszopiclone (Lunesta®) or zaleplon (Sonata®)
Trazodone (Deseryl®)– peak concentration 1hr nl, 2 hr with food
Should take consistently either with or without food
Buspirone (Buspar®) – bioavailability doubles with food
Paliperidone (Invega®) – increases with food
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