9-MBC (9-Methyl-β-carboline) Nootropic: Upgrading Dopamine To Increase Mood, Motivation & Libido. 9-Me-BC
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9-MBC (9-Methyl-β-carboline) Nootropic.
This video analyses the key Nootropic effects and scientific research conducted on 9-MBC.
Within the nootropic/smart drug community, 9-MBC has been used for:
-Reversing stimulant tolerance.
-Restoring sensitivity to dopaminergics.
-Recovering from drug abuse.
-Increasing motivation.
-Enhancing attention/focus.
-Increasing mood.
-Increasing libido.
9-MBC interacts with pathways of tyrosine hydroxylase regulation, including the FGF receptor,PKA, PKC and possibly the PI3K/Akt pathway (11).
Unexpectedly, 9-methyl-carboline (9-MBC), is taken up via the dopamine transporter and increased the cell number of dopaminergic neurons, while these additional tyrosine hydroxylase-immunoreactive neurons originated exclusively from nonproliferative, pre-existing dopa decarboxylase-positive neurons.
The stimulatory properties of 9-MBC were partly reversible when 9-MBC was withdrawn (11)
Protein and gene expression of tyrosine hydroxylase, as well as gene expression of tyrosine hydroxylase-relevant transcription factors (Nurr1, Pitx3, CREB, CREBBP, GATA2 and GATA3), was increased after 9-MBC treatment (11).
• Up-regulates, differentiates and protects dopaminergic neurons, dendrites and synapses, especially in the substantia nigra of the midbrain and in the hippocampus (1)(2)(6)(7)
• Increases dopamine synthesis (1)(7).
• Increases neurotrophins/neurotrophic factors (NGF, BDNF, CDNF [6], GDNF, SHH (5) and decrease apoptic signals (like caspase-3) (2)
• Decreases inflammation, preventing microglia proliferation and chemokine release [4], protecting against lipopolysaccharide toxicity (5) and reducing LDH (2)(6) (lactate dehydrogenase). Reduces α-synuclein (4)(5), the aggregation of which form insoluble fibrils (like lewy bodies), one of the causes of some neurodegenerative disorders, like PD and AD (alzheimer's disease)
• Increases TH (6) (tyrosine hydroxylase) expression and its transcription factors, and interacts with tyrosine kinases, TH converts L-tyrosine to L-Dopa, needed for the synthesis of the catecholamines, especially dopamine
• MAO-B inhibition (3), preventing the formation of neurotoxic substances, like DOPAC (from the dopamine metabolization), 6-OH-DA (oxydopamine), and MPDP⁺/MPP⁺ (from MPTP), the major cause of dopaminergic neurons death.
• Increases/protects/recovers the NADH dehydrogenase (or "complex I" (6) which catalyzes the transfer of electrons between NADH and Co-Q10), enhancing the mithocondrial respiration chain (7)
• Increase ATP (6)
Even when 9-MBC was administered chronically, it exerted no neurotoxic effects (11).
#nootropic
#Nootropics
#Dopamine
#Biohacking
DISCLAIMER:
The information provided in this video is for entertainment purposes only and IS NOT MEDICAL ADVICE. If you have questions about your health contact a medical professional.This content is strictly the opinion of Lucas Aoun and is for informational and educational purposes only. It is not intended to provide medical advice or to take the place of medical advice or treatment from a personal physician. All viewers of this content are advised to consult their doctors or qualified health professionals regarding specific health questions. Neither Lucas Aoun nor the publisher of this content takes responsibility for possible health consequences of any person or persons reading or following the information in this educational content. All viewers of this content, especially those taking prescription or over-the-counter medications, should consult their physicians before beginning any nutrition, supplement or lifestyle program.
